Assay Detail
Binding
CHEMBL4708891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild-type full-length human liver FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate by malachite green dye based assay
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 60 | 5.78 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4740651 | — | — | 1 | 6.89 |
| CHEMBL4098129 | — | — | 1 | 6.66 |
| CHEMBL4085566 | — | — | 1 | 6.52 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | — | 1 | 6.51 |
| CHEMBL4063998 | — | — | 1 | 6.33 |
| CHEMBL4740022 | — | — | 1 | 6.31 |
| CHEMBL4750573 | — | — | 1 | 6.25 |
| CHEMBL4756633 | — | — | 1 | 6.22 |
| CHEMBL4754762 | — | — | 1 | 5.92 |
| CHEMBL4752001 | — | — | 1 | 5.90 |
| CHEMBL4784382 | — | — | 1 | 5.89 |
| CHEMBL4635138 | — | — | 1 | 5.81 |
| CHEMBL964 | DISULFIRAM | 4.0 | 1 | 5.75 |
| CHEMBL4787013 | — | — | 1 | 5.71 |
| CHEMBL4129122 | — | — | 1 | 5.69 |
| CHEMBL4126492 | — | — | 1 | 5.69 |
| CHEMBL4755624 | — | — | 1 | 5.66 |
| CHEMBL4747571 | — | — | 1 | 5.65 |
| CHEMBL752 | ADENOSINE PHOSPHATE | 4.0 | 1 | 5.64 |
| CHEMBL120563 | THIRAM | 2.0 | 1 | 5.64 |
| CHEMBL583959 | BIS(PYRROLIDINYLTHIOCARBONYL)DISULFIDE | — | 1 | 5.64 |
| CHEMBL4754477 | — | — | 1 | 5.60 |
| CHEMBL4080882 | — | — | 1 | 5.57 |
| CHEMBL4799901 | — | — | 1 | 5.48 |
| CHEMBL4741096 | — | — | 1 | 5.42 |
| CHEMBL4751375 | — | — | 1 | 5.35 |
| CHEMBL4762915 | — | — | 1 | 5.27 |
| CHEMBL4127883 | — | — | 1 | 5.18 |
| CHEMBL4794960 | — | — | 1 | 5.12 |
| CHEMBL121516 | BIS(PIPERIDINYLTHIOCARBONYL)DISULFIDE | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4740651 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4098129 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4085566 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4063998 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4740022 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4750573 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4756633 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4754762 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4752001 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4784382 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL4635138 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL964 | DISULFIRAM | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4787013 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL4126492 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4129122 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4755624 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4747571 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL752 | ADENOSINE PHOSPHATE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL120563 | THIRAM | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL583959 | BIS(PYRROLIDINYLTHIOCARBONYL)DISULFIDE | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4754477 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4080882 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL4799901 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4741096 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL4751375 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL4762915 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL4127883 | — | IC50 | = | 6640.0 | nM | 5.18 |
| CHEMBL4794960 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL121516 | BIS(PIPERIDINYLTHIOCARBONYL)DISULFIDE | IC50 | = | 8780.0 | nM | 5.06 |
| CHEMBL3185770 | — | IC50 | = | 12230.0 | nM | 4.91 |
| CHEMBL4757164 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL121556 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4758888 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4798394 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4751677 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4750782 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4776673 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4780805 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL571274 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4789930 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL570804 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4760573 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4757113 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2004297 | SULFIRAM | IC50 | > | 10000.0 | nM | - |
| CHEMBL582931 | (DIETHYLTHIOCARBAMOYL)METHYLENE DIETHYLCARBAMODITHIOATE | IC50 | > | 10000.0 | nM | - |
| CHEMBL569414 | (DIETHYLCARBAMOYL)METHYLENE DIETHYLCARBAMODITHIOATE | IC50 | > | 10000.0 | nM | - |
| CHEMBL4214871 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL570813 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4756189 | — | IC50 | > | 10000.0 | nM | - |