Assay Detail
Binding
CHEMBL4709162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to His-tagged human ERCC1-XPF expressed in Escherichia coli BL21 (DE3) cells by steady-state fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
DNA excision repair protein ERCC-1/DNA repair endonuclease XPF (CHEMBL3883316) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.96 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4759590 | — | — | 1 | 7.07 |
| CHEMBL463783 | — | — | 1 | 6.85 |
| CHEMBL4783305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4759590 | — | Kd | = | 85.0 | nM | 7.07 |
| CHEMBL463783 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL4783305 | — | Kd | - | — | - |