Assay Detail
Binding
CHEMBL4709191
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Inhibition of c-MET(unknown origin) using FAM labelled peptide substrate preincubated for 10 mins followed by substrate addition and measured by microplate reader method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel c-Mesenchymal-Epithelia transition factor and histone deacetylase dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.88 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4758378 | — | — | 1 | 8.27 |
| CHEMBL4798120 | — | — | 1 | 8.13 |
| CHEMBL4740648 | — | — | 1 | 7.85 |
| CHEMBL4748100 | — | — | 1 | 7.70 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 7.43 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4758378 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4798120 | — | IC50 | = | 7.42 | nM | 8.13 |
| CHEMBL4740648 | — | IC50 | = | 14.23 | nM | 7.85 |
| CHEMBL4748100 | — | IC50 | = | 19.86 | nM | 7.70 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 37.28 | nM | 7.43 |
| CHEMBL98 | VORINOSTAT | IC50 | - | — | - |