Assay Detail
Binding
CHEMBL4709846
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoquinolinone derivatives as potent CNS multi-receptor D/5-HT/5-HT/5-HT/5-HT agents: Synthesis and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.43 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764679 | — | — | 1 | 8.31 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.39 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.05 |
| CHEMBL4743324 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764679 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL85 | RISPERIDONE | Ki | = | 40.7 | nM | 7.39 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 89.4 | nM | 7.05 |
| CHEMBL4743324 | — | Ki | = | 108.7 | nM | 6.96 |