Assay Detail
Binding
CHEMBL4709934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in CHO-K1 cells by microbeta scintillation analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design of new multitarget histamine H receptor ligands as potential candidates for treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.68 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462605 | PITOLISANT | 4.0 | 1 | 7.52 |
| CHEMBL4757387 | — | — | 1 | 7.25 |
| CHEMBL4789324 | — | — | 1 | 7.07 |
| CHEMBL4777210 | — | — | 1 | 7.01 |
| CHEMBL4783624 | — | — | 1 | 7.00 |
| CHEMBL4796334 | — | — | 1 | 7.00 |
| CHEMBL4797681 | — | — | 1 | 6.96 |
| CHEMBL4786252 | — | — | 1 | 6.85 |
| CHEMBL4784081 | — | — | 1 | 6.83 |
| CHEMBL4798732 | — | — | 1 | 6.82 |
| CHEMBL4759463 | — | — | 1 | 6.81 |
| CHEMBL4797355 | — | — | 1 | 6.77 |
| CHEMBL4750579 | — | — | 1 | 6.76 |
| CHEMBL4797867 | — | — | 1 | 6.69 |
| CHEMBL4747044 | — | — | 1 | 6.62 |
| CHEMBL4785098 | — | — | 1 | 6.55 |
| CHEMBL4790939 | — | — | 1 | 6.36 |
| CHEMBL4784025 | — | — | 1 | 6.35 |
| CHEMBL4784501 | — | — | 1 | 6.33 |
| CHEMBL4744451 | — | — | 1 | 6.30 |
| CHEMBL4741039 | — | — | 1 | 6.28 |
| CHEMBL4746282 | — | — | 1 | 6.22 |
| CHEMBL4794003 | — | — | 1 | 5.97 |
| CHEMBL4793206 | — | — | 1 | 5.96 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | - |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462605 | PITOLISANT | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4757387 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL4789324 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL4777210 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL4783624 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4796334 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4797681 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4786252 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4784081 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL4798732 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4759463 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL4797355 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4750579 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL4797867 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL4747044 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL4785098 | — | Ki | = | 282.0 | nM | 6.55 |
| CHEMBL4790939 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL4784025 | — | Ki | = | 448.0 | nM | 6.35 |
| CHEMBL4784501 | — | Ki | = | 465.0 | nM | 6.33 |
| CHEMBL4744451 | — | Ki | = | 496.0 | nM | 6.30 |
| CHEMBL4741039 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL4746282 | — | Ki | = | 602.0 | nM | 6.22 |
| CHEMBL4794003 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL4793206 | — | Ki | = | 1105.0 | nM | 5.96 |
| CHEMBL887 | RASAGILINE | Ki | - | — | - | |
| CHEMBL396778 | SAFINAMIDE | Ki | - | — | - | |
| CHEMBL8706 | CLORGILINE | Ki | - | — | - |