Assay Detail
Binding
CHEMBL4710183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant NPP1 expressed in COS-7 cell membrane at 100 uM using p-nitrophenyl thymidine monophosphate substrate incubated for 35 mins by spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (CHEMBL5925) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.65 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747297 | — | — | 1 | 6.82 |
| CHEMBL4793019 | — | — | 1 | 6.38 |
| CHEMBL4758988 | — | — | 1 | 5.84 |
| CHEMBL4753995 | — | — | 1 | 5.62 |
| CHEMBL4741253 | — | — | 1 | 5.59 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 5.11 |
| CHEMBL4761471 | — | — | 1 | 5.04 |
| CHEMBL4759734 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747297 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4793019 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4758988 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL4753995 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL4741253 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL265502 | SURAMIN | IC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL4761471 | — | IC50 | = | 9230.0 | nM | 5.04 |
| CHEMBL4759734 | — | IC50 | = | 17200.0 | nM | 4.76 |