Assay Detail
Functional
CHEMBL4710313
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Antiviral activity against HIV1 harboring RT K103N/Y181C double mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect by MTT assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 6.09 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.34 |
| CHEMBL4784247 | — | — | 1 | 8.21 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.80 |
| CHEMBL4755777 | — | — | 1 | 7.63 |
| CHEMBL4759261 | — | — | 1 | 6.96 |
| CHEMBL1766209 | — | — | 1 | 6.52 |
| CHEMBL4800322 | — | — | 1 | 6.48 |
| CHEMBL4743821 | — | — | 1 | 6.22 |
| CHEMBL85059 | — | — | 1 | 6.19 |
| CHEMBL4749320 | — | — | 1 | 6.18 |
| CHEMBL127012 | — | — | 1 | 6.16 |
| CHEMBL4747527 | — | — | 1 | 6.15 |
| CHEMBL4780972 | — | — | 1 | 6.01 |
| CHEMBL4776949 | — | — | 1 | 5.95 |
| CHEMBL4745751 | — | — | 1 | 5.74 |
| CHEMBL4744227 | — | — | 1 | 5.49 |
| CHEMBL4739864 | — | — | 1 | 5.48 |
| CHEMBL4776145 | — | — | 1 | 5.45 |
| CHEMBL4788245 | — | — | 1 | 5.44 |
| CHEMBL4760961 | — | — | 1 | 5.37 |
| CHEMBL4788280 | — | — | 1 | 5.33 |
| CHEMBL4800185 | — | — | 1 | 5.28 |
| CHEMBL4747243 | — | — | 1 | 5.21 |
| CHEMBL283950 | L-737126 | — | 1 | 5.10 |
| CHEMBL4794256 | — | — | 1 | 4.85 |
| CHEMBL4776821 | — | — | 1 | 4.71 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | - |
| CHEMBL4798552 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4784247 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4755777 | — | EC50 | = | 23.5 | nM | 7.63 |
| CHEMBL4759261 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1766209 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4800322 | — | EC50 | = | 331.0 | nM | 6.48 |
| CHEMBL4743821 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL85059 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4749320 | — | EC50 | = | 662.0 | nM | 6.18 |
| CHEMBL127012 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4747527 | — | EC50 | = | 704.0 | nM | 6.15 |
| CHEMBL4780972 | — | EC50 | = | 967.0 | nM | 6.01 |
| CHEMBL4776949 | — | EC50 | = | 1123.0 | nM | 5.95 |
| CHEMBL4745751 | — | EC50 | = | 1808.0 | nM | 5.74 |
| CHEMBL4744227 | — | EC50 | = | 3237.0 | nM | 5.49 |
| CHEMBL4739864 | — | EC50 | = | 3292.0 | nM | 5.48 |
| CHEMBL4776145 | — | EC50 | = | 3555.0 | nM | 5.45 |
| CHEMBL4788245 | — | EC50 | = | 3667.0 | nM | 5.44 |
| CHEMBL4760961 | — | EC50 | = | 4307.0 | nM | 5.37 |
| CHEMBL4788280 | — | EC50 | = | 4621.0 | nM | 5.33 |
| CHEMBL4800185 | — | EC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL4747243 | — | EC50 | = | 6089.0 | nM | 5.21 |
| CHEMBL283950 | L-737126 | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4794256 | — | EC50 | = | 14270.0 | nM | 4.85 |
| CHEMBL4776821 | — | EC50 | = | 19533.0 | nM | 4.71 |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 3756.0 | nM | - |
| CHEMBL223228 | EFAVIRENZ | EC50 | > | 317.0 | nM | - |
| CHEMBL4798552 | — | EC50 | > | 19718.0 | nM | - |