Assay Detail
Functional
CHEMBL4710384
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Antiproliferative activity against human HT29 cells incubated for 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.05 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957266 | — | — | 1 | 6.32 |
| CHEMBL4779984 | — | — | 1 | 5.50 |
| CHEMBL4752543 | — | — | 1 | 5.32 |
| CHEMBL4749568 | — | — | 1 | 5.17 |
| CHEMBL4743540 | — | — | 1 | 5.02 |
| CHEMBL4760233 | — | — | 1 | 4.98 |
| CHEMBL4758501 | — | — | 1 | 4.88 |
| CHEMBL4754483 | — | — | 1 | 4.84 |
| CHEMBL2179387 | — | — | 1 | 4.83 |
| CHEMBL4783083 | — | — | 1 | 4.78 |
| CHEMBL4792207 | — | — | 1 | 4.71 |
| CHEMBL4742931 | — | — | 1 | 4.63 |
| CHEMBL4758631 | — | — | 1 | 4.61 |
| CHEMBL4748720 | — | — | 1 | - |
| CHEMBL4756652 | — | — | 1 | - |
| CHEMBL4798353 | — | — | 1 | - |
| CHEMBL4796758 | — | — | 1 | - |
| CHEMBL4744677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957266 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4779984 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4752543 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL4749568 | — | IC50 | = | 6680.0 | nM | 5.17 |
| CHEMBL4743540 | — | IC50 | = | 9470.0 | nM | 5.02 |
| CHEMBL4760233 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4758501 | — | IC50 | = | 13040.0 | nM | 4.88 |
| CHEMBL4754483 | — | IC50 | = | 14480.0 | nM | 4.84 |
| CHEMBL2179387 | — | IC50 | = | 14720.0 | nM | 4.83 |
| CHEMBL4783083 | — | IC50 | = | 16590.0 | nM | 4.78 |
| CHEMBL4792207 | — | IC50 | = | 19650.0 | nM | 4.71 |
| CHEMBL4742931 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL4758631 | — | IC50 | = | 24420.0 | nM | 4.61 |
| CHEMBL4748720 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4756652 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4798353 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4796758 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4744677 | — | IC50 | > | 50000.0 | nM | - |