Compound Detail
CHEMBL4796758
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Basic Information
| ChEMBL ID | CHEMBL4796758 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NLGBELQKKLLKJT-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
378.4
MW (Da)
4.39
ALogP
3
HBA
2
HBD
75.3
PSA (Ų)
0.66
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 CHEMBL1163125 | IC50 | 6.69 | 6.69 | 203.0 | 1 |
| HL-60 CHEMBL383 | IC50 | 5.47 | 5.47 | 3360.0 | 1 |
| WI-38 CHEMBL614391 | IC50 | 4.83 | 4.83 | 14620.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | IC50 | = | 203.0 | nM | 6.69 | Inhibition of BRD4 BD1 (unknown origin) preincubated for 15 mins followed by pep... | 32883643 |
| HL-60 | IC50 | = | 3360.0 | nM | 5.47 | Antiproliferative activity against human HL60 cells incubated for 72 hrs by CCK8... | 32883643 |
| WI-38 | IC50 | = | 14620.0 | nM | 4.83 | Antiproliferative activity against human WI-38 cells incubated for 72 hrs by MTT... | 32883643 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32883643 | 10.1016/j.ejmech.2020.112780 | Bromodomain-containing protein 4 | 2 |
| 32883643 | 10.1016/j.ejmech.2020.112780 | HL-60 | 1 |
| 32883643 | 10.1016/j.ejmech.2020.112780 | HT-29 | 1 |
| 32883643 | 10.1016/j.ejmech.2020.112780 | WI-38 | 1 |
Data from ChEMBL 36 via Core Engine