Assay Detail
ADMET
CHEMBL4710385
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Antiproliferative activity against human WI-38 cells incubated for 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | WI-38 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.81 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957266 | — | — | 1 | 5.30 |
| CHEMBL4743540 | — | — | 1 | 5.29 |
| CHEMBL4779984 | — | — | 1 | 5.23 |
| CHEMBL4760233 | — | — | 1 | 5.07 |
| CHEMBL4758501 | — | — | 1 | 5.05 |
| CHEMBL4742931 | — | — | 1 | 5.00 |
| CHEMBL4749568 | — | — | 1 | 5.00 |
| CHEMBL4754483 | — | — | 1 | 4.96 |
| CHEMBL4744677 | — | — | 1 | 4.89 |
| CHEMBL4796758 | — | — | 1 | 4.83 |
| CHEMBL4758631 | — | — | 1 | 4.79 |
| CHEMBL2179387 | — | — | 1 | 4.70 |
| CHEMBL4748720 | — | — | 1 | 4.61 |
| CHEMBL4792207 | — | — | 1 | 4.54 |
| CHEMBL4756652 | — | — | 1 | 4.49 |
| CHEMBL4752543 | — | — | 1 | 4.36 |
| CHEMBL4783083 | — | — | 1 | 4.33 |
| CHEMBL4798353 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957266 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL4743540 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL4779984 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL4760233 | — | IC50 | = | 8550.0 | nM | 5.07 |
| CHEMBL4758501 | — | IC50 | = | 8950.0 | nM | 5.05 |
| CHEMBL4742931 | — | IC50 | = | 9970.0 | nM | 5.00 |
| CHEMBL4749568 | — | IC50 | = | 9980.0 | nM | 5.00 |
| CHEMBL4754483 | — | IC50 | = | 10890.0 | nM | 4.96 |
| CHEMBL4744677 | — | IC50 | = | 12940.0 | nM | 4.89 |
| CHEMBL4796758 | — | IC50 | = | 14620.0 | nM | 4.83 |
| CHEMBL4758631 | — | IC50 | = | 16140.0 | nM | 4.79 |
| CHEMBL2179387 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4748720 | — | IC50 | = | 24780.0 | nM | 4.61 |
| CHEMBL4792207 | — | IC50 | = | 28750.0 | nM | 4.54 |
| CHEMBL4756652 | — | IC50 | = | 32770.0 | nM | 4.49 |
| CHEMBL4752543 | — | IC50 | = | 44070.0 | nM | 4.36 |
| CHEMBL4783083 | — | IC50 | = | 47140.0 | nM | 4.33 |
| CHEMBL4798353 | — | IC50 | = | 84420.0 | nM | 4.07 |