Assay Detail
Binding
CHEMBL4710579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of androgen receptor (unknown origin)
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New drug approvals for 2019: Synthesis and clinical applications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.35 | 7.96 |
| IC50 | 3 | 6.98 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297185 | DAROLUTAMIDE | 4.0 | 2 | 7.96 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 2 | 7.07 |
| CHEMBL3183409 | APALUTAMIDE | 4.0 | 2 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297185 | DAROLUTAMIDE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4297185 | DAROLUTAMIDE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1082407 | ENZALUTAMIDE | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL3183409 | APALUTAMIDE | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL3183409 | APALUTAMIDE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 219.0 | nM | 6.66 |