Assay Detail
ADMET
CHEMBL4711538
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Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.40 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569157 | — | — | 1 | 4.89 |
| CHEMBL4755787 | — | — | 1 | 4.72 |
| CHEMBL569379 | — | — | 1 | 4.72 |
| CHEMBL4784920 | — | — | 1 | 4.60 |
| CHEMBL4778209 | — | — | 1 | 4.54 |
| CHEMBL583256 | — | — | 1 | 4.47 |
| CHEMBL4792832 | — | — | 1 | 4.38 |
| CHEMBL4785448 | — | — | 1 | 4.30 |
| CHEMBL4098597 | — | — | 1 | 4.29 |
| CHEMBL4776282 | — | — | 1 | 4.28 |
| CHEMBL4763590 | — | — | 1 | 4.24 |
| CHEMBL4741859 | — | — | 1 | 4.17 |
| CHEMBL4762586 | — | — | 1 | 4.16 |
| CHEMBL4790077 | — | — | 1 | 4.14 |
| CHEMBL4746300 | — | — | 1 | 4.14 |
| CHEMBL1836445 | — | — | 1 | - |
| CHEMBL1836443 | — | — | 1 | - |
| CHEMBL4796885 | — | — | 1 | - |
| CHEMBL471108 | — | — | 1 | - |
| CHEMBL3608949 | — | — | 1 | - |
| CHEMBL4078293 | — | — | 1 | - |
| CHEMBL4090270 | — | — | 1 | - |
| CHEMBL4776970 | — | — | 1 | - |
| CHEMBL4776598 | — | — | 1 | - |
| CHEMBL4091850 | — | — | 1 | - |
| CHEMBL4760509 | — | — | 1 | - |
| CHEMBL4097978 | — | — | 1 | - |
| CHEMBL4792815 | — | — | 1 | - |
| CHEMBL4783283 | — | — | 1 | - |
| CHEMBL4105162 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569157 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4755787 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL569379 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4784920 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4778209 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL583256 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4792832 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL4785448 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4098597 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL4776282 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL4763590 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4741859 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4762586 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL4790077 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL4746300 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4764892 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4746261 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4066553 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4095540 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1836445 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1836443 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4796885 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL471108 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608949 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4078293 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4090270 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4776970 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4776598 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4091850 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4760509 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4097978 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4792815 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4783283 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4105162 | — | IC50 | > | 100000.0 | nM | - |