Assay Detail
Binding
CHEMBL4711560
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Inhibition of Trypanosoma cruzi Tulahuen C4 strain CYP51 expressed in Escherichia coli by fluorescence based assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.62 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 8.28 |
| CHEMBL3787254 | — | — | 1 | 6.80 |
| CHEMBL3785246 | — | — | 1 | 6.28 |
| CHEMBL4778209 | — | — | 1 | 5.12 |
| CHEMBL1836445 | — | — | 1 | - |
| CHEMBL1836443 | — | — | 1 | - |
| CHEMBL4746300 | — | — | 1 | - |
| CHEMBL4784920 | — | — | 1 | - |
| CHEMBL4098597 | — | — | 1 | - |
| CHEMBL4078293 | — | — | 1 | - |
| CHEMBL4762238 | — | — | 1 | - |
| CHEMBL4796920 | — | — | 1 | - |
| CHEMBL4783283 | — | — | 1 | - |
| CHEMBL4066553 | — | — | 1 | - |
| CHEMBL4091850 | — | — | 1 | - |
| CHEMBL4105162 | — | — | 1 | - |
| CHEMBL4077167 | — | — | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | - |
| CHEMBL3786030 | — | — | 1 | - |
| CHEMBL3786506 | — | — | 1 | - |
| CHEMBL3787410 | — | — | 1 | - |
| CHEMBL4756338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3787254 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3785246 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4778209 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL1836445 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1836443 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4746300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4784920 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4098597 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4078293 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4762238 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4796920 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4783283 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4066553 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4091850 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4105162 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4077167 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL110 | BENZNIDAZOLE | IC50 | > | 10000.0 | nM | - |
| CHEMBL290960 | NIFURTIMOX | IC50 | > | 10000.0 | nM | - |
| CHEMBL3786030 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3786506 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3787410 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4756338 | — | IC50 | > | 10000.0 | nM | - |