Assay Detail
Functional
CHEMBL4712181
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Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Flp-In-T-REx-293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.34 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3715656 | — | — | 1 | 7.68 |
| CHEMBL3715918 | — | — | 1 | 7.26 |
| CHEMBL3717743 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3715656 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3715918 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3717743 | — | IC50 | = | 86.0 | nM | 7.07 |