Assay Detail
Functional
CHEMBL4712295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by WST-1 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.03 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399894 | — | — | 1 | 7.30 |
| CHEMBL459546 | — | — | 1 | 7.17 |
| CHEMBL250451 | BRUCEINE A | — | 1 | 7.09 |
| CHEMBL140809 | BRUCEINE B | — | 1 | 7.00 |
| CHEMBL251697 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399894 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL459546 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL250451 | BRUCEINE A | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL140809 | BRUCEINE B | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL251697 | — | IC50 | = | 250.0 | nM | 6.60 |