Assay Detail
Functional
CHEMBL4712372
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Cytotoxicity against human HCT116 cells incubated for 72 hrs by ATPlite assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.45 | 8.00 |
| EC50 | 1 | 6.60 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4753454 | — | — | 1 | 8.00 |
| CHEMBL4787610 | — | — | 1 | 7.24 |
| CHEMBL4799961 | — | — | 1 | 7.09 |
| CHEMBL4757460 | — | — | 1 | 7.04 |
| CHEMBL453157 | DICHAPETALIN A | — | 1 | 6.60 |
| CHEMBL4785790 | — | — | 1 | 6.35 |
| CHEMBL4791307 | — | — | 1 | 6.33 |
| CHEMBL4776530 | — | — | 1 | 6.30 |
| CHEMBL4753092 | — | — | 1 | 6.05 |
| CHEMBL4744816 | — | — | 1 | 5.60 |
| CHEMBL4752487 | — | — | 1 | 5.52 |
| CHEMBL4759525 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4753454 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4787610 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4799961 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4757460 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL453157 | DICHAPETALIN A | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4785790 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4791307 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4776530 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4753092 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4744816 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4752487 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4759525 | — | IC50 | = | 4200.0 | nM | 5.38 |