Assay Detail
Functional
CHEMBL4712758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.35 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.40 |
| CHEMBL4744476 | — | — | 1 | 6.85 |
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 6.24 |
| CHEMBL4751346 | — | — | 1 | 6.09 |
| CHEMBL4755821 | — | — | 1 | 5.80 |
| CHEMBL4764464 | — | — | 1 | 5.78 |
| CHEMBL4753867 | — | — | 1 | 5.75 |
| CHEMBL4788848 | — | — | 1 | 5.70 |
| CHEMBL4742019 | — | — | 1 | 5.52 |
| CHEMBL4634483 | — | — | 1 | 5.43 |
| CHEMBL4764594 | — | — | 1 | 5.22 |
| CHEMBL4777562 | — | — | 1 | 5.15 |
| CHEMBL4758898 | — | — | 1 | 4.70 |
| CHEMBL4790411 | — | — | 1 | 4.58 |
| CHEMBL4751562 | — | — | 1 | 4.54 |
| CHEMBL4787773 | — | — | 1 | 4.54 |
| CHEMBL4758694 | — | — | 1 | 4.47 |
| CHEMBL4783188 | — | — | 1 | 4.47 |
| CHEMBL4794928 | — | — | 1 | 4.43 |
| CHEMBL4793136 | — | — | 1 | 4.25 |
| CHEMBL4079082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4744476 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2016757 | GS-441524 | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4751346 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4755821 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4764464 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL4753867 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4788848 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4742019 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL4634483 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL4764594 | — | IC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL4777562 | — | IC50 | = | 7060.0 | nM | 5.15 |
| CHEMBL4758898 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4790411 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL4751562 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4787773 | — | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL4758694 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL4783188 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL4794928 | — | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL4793136 | — | IC50 | = | 55700.0 | nM | 4.25 |
| CHEMBL4079082 | — | IC50 | < | 250.0 | nM | - |