Assay Detail
Binding
CHEMBL4713191
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Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.48 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | — | 1 | 5.80 |
| CHEMBL113830 | (S,R)-IFENPRODIL | — | 1 | 5.64 |
| CHEMBL493054 | — | — | 1 | 5.26 |
| CHEMBL319706 | (S)-IFENPRODIL | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL113830 | (S,R)-IFENPRODIL | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL493054 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL319706 | (S)-IFENPRODIL | Ki | = | 6100.0 | nM | 5.21 |