Compound Detail
CHEMBL49623
(R,S)-IFENPRODIL Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL49623 |
| Name | (R,S)-IFENPRODIL |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UYNVMODNBIQBMV-KKSFZXQISA-N |
16
Targets
27
Activities
3
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
325.4
MW (Da)
3.77
ALogP
3
HBA
2
HBD
43.7
PSA (Ų)
0.88
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 15 meas. best 8.34
IC50 10 meas. best 7.0
Kd 2 meas. best 8.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma intracellular receptor 2 CHEMBL4105864 | Ki | 8.34 | 7.675 | 4.6 | 2 |
| Glutamate receptor ionotropic, NMDA 2B CHEMBL1904 | Kd | 8.12 | 7.575 | 7.6 | 2 |
| Unchecked CHEMBL612545 | Ki | 8.0 | 7.945 | 10.0 | 2 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | Ki | 7.92 | 7.92 | 12.0 | 1 |
| Glutamate [NMDA] receptor CHEMBL2094124 | Ki | 7.89 | 7.89 | 13.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2B CHEMBL1904 | Ki | 7.84 | 7.84 | 14.4 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL4153 | Ki | 7.66 | 7.28 | 22.0 | 2 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | Ki | 7.02 | 7.02 | 95.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | IC50 | 7.0 | 6.8825 | 100.0 | 4 |
| Glutamate NMDA receptor; Grin1/Grin2b CHEMBL2096666 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 6.96 | 6.77 | 110.0 | 2 |
| Alpha-1A adrenergic receptor CHEMBL229 | Ki | 6.85 | 6.85 | 140.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2B CHEMBL1904 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2C CHEMBL401 | IC50 | 6.58 | 6.58 | 263.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 6.38 | 6.38 | 421.0 | 1 |
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 6.29 | 6.29 | 513.0 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 6.13 | 6.13 | 748.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 5.8 | 5.8 | 1600.0 | 1 |
| Glutamate NMDA receptor; Grin1/Grin2a CHEMBL2096680 | IC50 | 4.7 | 4.7 | 20000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine