Assay Detail
Binding
CHEMBL646863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for alpha-1 adrenergic receptor in rat was determined by [3H]- prazosin binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.81 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | — | 1 | 6.66 |
| CHEMBL54778 | — | — | 1 | 6.33 |
| CHEMBL102659 | — | — | 1 | 6.09 |
| CHEMBL449704 | — | — | 1 | 5.80 |
| CHEMBL103472 | — | — | 1 | 5.75 |
| CHEMBL28564 | ELIPRODIL | 2.0 | 1 | 5.48 |
| CHEMBL317229 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL54778 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL102659 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL449704 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL103472 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL28564 | ELIPRODIL | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL317229 | — | IC50 | = | 27000.0 | nM | 4.57 |