Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL645239

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against alpha-1 adrenergic receptor
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor alpha-1 (CHEMBL1907610)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds.
Chenard BL, Shalaby IA, Koe BK, Ronau RT, Butler TW, Prochniak MA, Schmidt AW, Fox CB.
J Med Chem (1991) 34 : 3085 -3090
PubMed 1681106 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.20 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL106970 1 6.89
CHEMBL49623 (R,S)-IFENPRODIL 1 6.87
CHEMBL104625 1 6.66
CHEMBL18222 1 6.46
CHEMBL321349 1 6.40
CHEMBL102242 1 6.24
CHEMBL319706 (S)-IFENPRODIL 2 6.20
CHEMBL106969 1 5.67
CHEMBL323338 1 5.59
CHEMBL104363 1 5.54
CHEMBL318347 1 -
CHEMBL322633 1 -
CHEMBL102212 1 -
CHEMBL104318 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL106970 IC50 = 130.0 nM 6.89
CHEMBL49623 (R,S)-IFENPRODIL IC50 = 135.0 nM 6.87
CHEMBL104625 IC50 = 220.0 nM 6.66
CHEMBL18222 IC50 = 347.0 nM 6.46
CHEMBL321349 IC50 = 400.0 nM 6.40
CHEMBL102242 IC50 = 573.0 nM 6.24
CHEMBL319706 (S)-IFENPRODIL IC50 = 629.0 nM 6.20
CHEMBL106969 IC50 = 2133.0 nM 5.67
CHEMBL319706 (S)-IFENPRODIL IC50 = 2306.0 nM 5.64
CHEMBL323338 IC50 = 2566.0 nM 5.59
CHEMBL104363 IC50 = 2867.0 nM 5.54
CHEMBL318347 IC50 > 10000.0 nM -
CHEMBL322633 IC50 > 10000.0 nM -
CHEMBL102212 IC50 > 10000.0 nM -
CHEMBL104318 IC50 > 10000.0 nM -