Assay Detail
Binding
CHEMBL645793
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In vitro binding affinity against Alpha-1 adrenergic receptor using [3H]prazosin as radioligand
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.66 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | — | 1 | 7.00 |
| CHEMBL420289 | — | — | 1 | 6.86 |
| CHEMBL319706 | (S)-IFENPRODIL | — | 1 | 6.07 |
| CHEMBL107075 | — | — | 1 | 5.83 |
| CHEMBL107104 | — | — | 1 | 5.66 |
| CHEMBL106191 | — | — | 1 | 5.64 |
| CHEMBL105870 | — | — | 1 | 5.63 |
| CHEMBL108120 | — | — | 1 | 5.57 |
| CHEMBL109121 | — | — | 1 | 5.50 |
| CHEMBL262807 | — | — | 1 | 5.33 |
| CHEMBL17350 | TRAXOPRODIL | 2.0 | 2 | 5.24 |
| CHEMBL106650 | — | — | 1 | 5.16 |
| CHEMBL321758 | — | — | 1 | 5.07 |
| CHEMBL321428 | — | — | 1 | - |
| CHEMBL107055 | — | — | 1 | - |
| CHEMBL102212 | — | — | 1 | - |
| CHEMBL431867 | — | — | 1 | - |
| CHEMBL107148 | — | — | 1 | - |
| CHEMBL104314 | — | — | 1 | - |
| CHEMBL107303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL420289 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL319706 | (S)-IFENPRODIL | IC50 | = | 843.0 | nM | 6.07 |
| CHEMBL107075 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL107104 | — | IC50 | = | 2166.0 | nM | 5.66 |
| CHEMBL106191 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL105870 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL108120 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL109121 | — | IC50 | = | 3133.0 | nM | 5.50 |
| CHEMBL262807 | — | IC50 | = | 4633.0 | nM | 5.33 |
| CHEMBL17350 | TRAXOPRODIL | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL106650 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL321758 | — | IC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL17350 | TRAXOPRODIL | IC50 | = | 19520.0 | nM | 4.71 |
| CHEMBL321428 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL107055 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL102212 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL431867 | — | IC50 | - | nM | - | |
| CHEMBL107148 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL104314 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL107303 | — | IC50 | > | 10000.0 | nM | - |