Assay Detail
Binding
CHEMBL4713193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.09 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | — | 1 | 7.66 |
| CHEMBL113830 | (S,R)-IFENPRODIL | — | 1 | 7.12 |
| CHEMBL493054 | — | — | 1 | 7.02 |
| CHEMBL319706 | (S)-IFENPRODIL | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL113830 | (S,R)-IFENPRODIL | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL493054 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL319706 | (S)-IFENPRODIL | Ki | = | 278.0 | nM | 6.56 |