Assay Detail
Binding
CHEMBL872367
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Binding affinity towards Alpha-1 adrenergic receptor in rat brain using [3H]prazosin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.94 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | — | 1 | 7.92 |
| CHEMBL50872 | — | — | 1 | 6.37 |
| CHEMBL48743 | — | — | 1 | 5.89 |
| CHEMBL48915 | — | — | 1 | 5.82 |
| CHEMBL46779 | — | — | 1 | 5.66 |
| CHEMBL299294 | — | — | 1 | 5.64 |
| CHEMBL50166 | — | — | 1 | 5.50 |
| CHEMBL48366 | — | — | 1 | 5.42 |
| CHEMBL51594 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL50872 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL48743 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL48915 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL46779 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL299294 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL50166 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL48366 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL51594 | — | Ki | = | 5800.0 | nM | 5.24 |