Assay Detail
Functional
CHEMBL745941
Review assay metadata, readout intent, target linkage, and publication context from the same page.
N-methyl-D-aspartate glutamate receptor antagonistic activity in cell culture(CC)model
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.40 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319706 | (S)-IFENPRODIL | — | 3 | 7.88 |
| CHEMBL323338 | — | — | 1 | 7.00 |
| CHEMBL49623 | (R,S)-IFENPRODIL | — | 1 | 6.96 |
| CHEMBL106970 | — | — | 1 | 6.82 |
| CHEMBL104625 | — | — | 1 | 6.63 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 6.58 |
| CHEMBL18222 | — | — | 1 | 6.54 |
| CHEMBL102242 | — | — | 1 | 5.70 |
| CHEMBL321349 | — | — | 1 | 5.43 |
| CHEMBL106969 | — | — | 1 | 5.30 |
| CHEMBL104363 | — | — | 1 | 5.20 |
| CHEMBL262807 | — | — | 1 | 5.00 |
| CHEMBL318347 | — | — | 1 | - |
| CHEMBL322633 | — | — | 1 | - |
| CHEMBL102212 | — | — | 1 | - |
| CHEMBL104318 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319706 | (S)-IFENPRODIL | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL319706 | (S)-IFENPRODIL | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL319706 | (S)-IFENPRODIL | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL323338 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL49623 | (R,S)-IFENPRODIL | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL106970 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL104625 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL305187 | IFENPRODIL | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL18222 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL102242 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL321349 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL106969 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL104363 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL262807 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL102212 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL322633 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL318347 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL104318 | — | IC50 | > | 10000.0 | nM | - |