Assay Detail
Binding
CHEMBL644129
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Tested for the Alpha-1 adrenergic receptor affinity in a standard radioligand binding assay with [3H]- prazosin
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Oxindole N-Methyl-D-Aspartate (NMDA) antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.50 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | — | 1 | 7.00 |
| CHEMBL172807 | — | — | 1 | 7.00 |
| CHEMBL173092 | — | — | 1 | 6.74 |
| CHEMBL366809 | — | — | 1 | 6.46 |
| CHEMBL427116 | — | — | 1 | 6.15 |
| CHEMBL28564 | ELIPRODIL | 2.0 | 1 | 6.10 |
| CHEMBL319706 | (S)-IFENPRODIL | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49623 | (R,S)-IFENPRODIL | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL172807 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL173092 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL366809 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL427116 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL28564 | ELIPRODIL | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL319706 | (S)-IFENPRODIL | IC50 | = | 843.0 | nM | 6.07 |