Assay Detail
Binding
CHEMBL4713198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in CHO-K1 cells incubated for 1 hr by radioligand binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.39 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493054 | — | — | 1 | 6.47 |
| CHEMBL319706 | (S)-IFENPRODIL | — | 1 | 6.43 |
| CHEMBL49623 | (R,S)-IFENPRODIL | — | 1 | 6.38 |
| CHEMBL113830 | (S,R)-IFENPRODIL | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493054 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL319706 | (S)-IFENPRODIL | Ki | = | 369.0 | nM | 6.43 |
| CHEMBL49623 | (R,S)-IFENPRODIL | Ki | = | 421.0 | nM | 6.38 |
| CHEMBL113830 | (S,R)-IFENPRODIL | Ki | = | 510.0 | nM | 6.29 |