Assay Detail
Functional
CHEMBL4713358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H292 cells harboring wild-type EGFR by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H292 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.95 | 9.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747082 | — | — | 1 | 9.81 |
| CHEMBL4781799 | — | — | 1 | 9.80 |
| CHEMBL4781323 | — | — | 1 | 9.37 |
| CHEMBL4793880 | — | — | 1 | 9.17 |
| CHEMBL4796010 | — | — | 1 | 9.14 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 9.03 |
| CHEMBL4787215 | — | — | 1 | 8.94 |
| CHEMBL4760063 | — | — | 1 | 8.77 |
| CHEMBL4796376 | — | — | 1 | 8.58 |
| CHEMBL4749234 | — | — | 1 | 8.42 |
| CHEMBL4752548 | — | — | 1 | 8.32 |
| CHEMBL4748458 | — | — | 1 | 8.01 |
| CHEMBL4747980 | — | — | 1 | - |
| CHEMBL4758350 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747082 | — | IC50 | = | 0.156 | nM | 9.81 |
| CHEMBL4781799 | — | IC50 | = | 0.157 | nM | 9.80 |
| CHEMBL4781323 | — | IC50 | = | 0.432 | nM | 9.37 |
| CHEMBL4793880 | — | IC50 | = | 0.674 | nM | 9.17 |
| CHEMBL4796010 | — | IC50 | = | 0.718 | nM | 9.14 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 0.924 | nM | 9.03 |
| CHEMBL4787215 | — | IC50 | = | 1.141 | nM | 8.94 |
| CHEMBL4760063 | — | IC50 | = | 1.693 | nM | 8.77 |
| CHEMBL4796376 | — | IC50 | = | 2.626 | nM | 8.58 |
| CHEMBL4749234 | — | IC50 | = | 3.763 | nM | 8.42 |
| CHEMBL4752548 | — | IC50 | = | 4.807 | nM | 8.32 |
| CHEMBL4748458 | — | IC50 | = | 9.771 | nM | 8.01 |
| CHEMBL4747980 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL4758350 | — | IC50 | > | 10.0 | nM | - |