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Compound Detail

CHEMBL4758350

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C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C4CC4)c4ccccc34)n2)c(OC)cc1N1CCSCC1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4758350
Phase Preclinical
Structure Type MOL
InChI Key SEUPRPQSYFGJFS-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

526.7
MW (Da)
5.86
ALogP
8
HBA
2
HBD
84.3
PSA (Ų)
0.28
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H30N6O2S
MW 526.67
Aromatic Rings 4
Heavy Atoms 38
NP-Likeness -1.16

Activity Summary

IC50 2 meas. best 9.48

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NCI-H1975
CHEMBL614348
 IC50 9.48 9.48 0.3 1
PC-9
CHEMBL614102
 IC50 9.13 9.13 0.7 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NCI-H1975 IC50 = 0.333 nM 9.48 Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L8... 33429247
PC-9 IC50 = 0.734 nM 9.13 Antiproliferative activity against human PC-9 cells harboring EGFR L858R mutant ... 33429247

Literature References

PubMed DOI Target Context # Activities
33429247 10.1016/j.ejmech.2020.113019 PC-9 1
33429247 10.1016/j.ejmech.2020.113019 NCI-H1975 1
33429247 10.1016/j.ejmech.2020.113019 NCI-H292 1
33429247 10.1016/j.ejmech.2020.113019 Unchecked 1

Data from ChEMBL 36 via Core Engine