Assay Detail
Functional
CHEMBL4713357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.64 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 10.96 |
| CHEMBL4793880 | — | — | 1 | 10.68 |
| CHEMBL4760063 | — | — | 1 | 10.13 |
| CHEMBL4758350 | — | — | 1 | 9.48 |
| CHEMBL4787215 | — | — | 1 | 9.39 |
| CHEMBL4749234 | — | — | 1 | 9.35 |
| CHEMBL4748458 | — | — | 1 | 9.27 |
| CHEMBL4752548 | — | — | 1 | 9.26 |
| CHEMBL4747980 | — | — | 1 | 8.95 |
| CHEMBL4796376 | — | — | 1 | 8.89 |
| CHEMBL4781323 | — | — | 1 | - |
| CHEMBL4796010 | — | — | 1 | - |
| CHEMBL4781799 | — | — | 1 | - |
| CHEMBL4747082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 0.011 | nM | 10.96 |
| CHEMBL4793880 | — | IC50 | = | 0.021 | nM | 10.68 |
| CHEMBL4760063 | — | IC50 | = | 0.074 | nM | 10.13 |
| CHEMBL4758350 | — | IC50 | = | 0.333 | nM | 9.48 |
| CHEMBL4787215 | — | IC50 | = | 0.411 | nM | 9.39 |
| CHEMBL4749234 | — | IC50 | = | 0.445 | nM | 9.35 |
| CHEMBL4748458 | — | IC50 | = | 0.543 | nM | 9.27 |
| CHEMBL4752548 | — | IC50 | = | 0.544 | nM | 9.26 |
| CHEMBL4747980 | — | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL4796376 | — | IC50 | = | 1.301 | nM | 8.89 |
| CHEMBL4781323 | — | IC50 | = | 0.008 | nM | - |
| CHEMBL4796010 | — | IC50 | = | 0.008 | nM | - |
| CHEMBL4781799 | — | IC50 | = | 0.008 | nM | - |
| CHEMBL4747082 | — | IC50 | = | 0.009 | nM | - |