Assay Detail
Functional
CHEMBL4713356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PC-9 cells harboring EGFR L858R mutant by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.60 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 10.96 |
| CHEMBL4793880 | — | — | 1 | 10.36 |
| CHEMBL4760063 | — | — | 1 | 10.19 |
| CHEMBL4749234 | — | — | 1 | 9.69 |
| CHEMBL4787215 | — | — | 1 | 9.58 |
| CHEMBL4752548 | — | — | 1 | 9.36 |
| CHEMBL4748458 | — | — | 1 | 9.19 |
| CHEMBL4758350 | — | — | 1 | 9.13 |
| CHEMBL4796376 | — | — | 1 | 8.88 |
| CHEMBL4747980 | — | — | 1 | 8.63 |
| CHEMBL4781323 | — | — | 1 | - |
| CHEMBL4796010 | — | — | 1 | - |
| CHEMBL4781799 | — | — | 1 | - |
| CHEMBL4747082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 0.011 | nM | 10.96 |
| CHEMBL4793880 | — | IC50 | = | 0.044 | nM | 10.36 |
| CHEMBL4760063 | — | IC50 | = | 0.064 | nM | 10.19 |
| CHEMBL4749234 | — | IC50 | = | 0.203 | nM | 9.69 |
| CHEMBL4787215 | — | IC50 | = | 0.261 | nM | 9.58 |
| CHEMBL4752548 | — | IC50 | = | 0.435 | nM | 9.36 |
| CHEMBL4748458 | — | IC50 | = | 0.648 | nM | 9.19 |
| CHEMBL4758350 | — | IC50 | = | 0.734 | nM | 9.13 |
| CHEMBL4796376 | — | IC50 | = | 1.317 | nM | 8.88 |
| CHEMBL4747980 | — | IC50 | = | 2.325 | nM | 8.63 |
| CHEMBL4781323 | — | IC50 | = | 0.005 | nM | - |
| CHEMBL4796010 | — | IC50 | = | 0.004 | nM | - |
| CHEMBL4781799 | — | IC50 | = | 0.009 | nM | - |
| CHEMBL4747082 | — | IC50 | = | 0.005 | nM | - |