Assay Detail
Functional
CHEMBL4713467
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat glucagon receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation by FRET assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.52 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4749279 | — | — | 1 | 7.52 |
| CHEMBL439904 | — | — | 1 | - |
| CHEMBL414357 | EXENATIDE | 4.0 | 1 | - |
| CHEMBL4796216 | — | — | 1 | - |
| CHEMBL4748874 | — | — | 1 | - |
| CHEMBL4741000 | — | — | 1 | - |
| CHEMBL4759334 | — | — | 1 | - |
| CHEMBL4752195 | — | — | 1 | - |
| CHEMBL4751466 | — | — | 1 | - |
| CHEMBL4281479 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4749279 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL439904 | — | EC50 | - | — | - | |
| CHEMBL414357 | EXENATIDE | EC50 | - | — | - | |
| CHEMBL4796216 | — | EC50 | - | — | - | |
| CHEMBL4748874 | — | EC50 | - | — | - | |
| CHEMBL4741000 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL4759334 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL4752195 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL4751466 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL4281479 | — | EC50 | - | — | - |