Assay Detail
Functional
CHEMBL4713470
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation by FRET assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glucagon-like peptide 1 receptor (CHEMBL5862) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 9.62 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4749279 | — | — | 1 | 9.92 |
| CHEMBL4751466 | — | — | 1 | 9.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4749279 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL4751466 | — | EC50 | = | 0.48 | nM | 9.32 |