Assay Detail
Binding
CHEMBL4713554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ABCG2 (unknown origin) expressed in MDCK-II cells assessed as reduction in pheophorbide A efflux measured after 2 hrs by flow cytometry
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK-II |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Broad substrate specificity ATP-binding cassette transporter ABCG2 (CHEMBL5393) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rational drug design of 6-substituted 4-anilino-2-phenylpyrimidines for exploration of novel ABCG2 binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.51 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792783 | — | — | 1 | 7.02 |
| CHEMBL4761715 | — | — | 1 | 6.88 |
| CHEMBL4747679 | — | — | 1 | 6.85 |
| CHEMBL4752426 | — | — | 1 | 6.83 |
| CHEMBL4762956 | — | — | 1 | 6.77 |
| CHEMBL4069428 | — | — | 1 | 6.72 |
| CHEMBL4750965 | — | — | 1 | 6.68 |
| CHEMBL4798521 | — | — | 1 | 6.65 |
| CHEMBL4797455 | — | — | 1 | 6.56 |
| CHEMBL4800631 | — | — | 1 | 6.55 |
| CHEMBL4799327 | — | — | 1 | 6.53 |
| CHEMBL4741738 | — | — | 1 | 6.43 |
| CHEMBL4744165 | — | — | 1 | 6.41 |
| CHEMBL4794767 | — | — | 1 | 6.36 |
| CHEMBL4783240 | — | — | 1 | 6.30 |
| CHEMBL4754067 | — | — | 1 | 6.22 |
| CHEMBL4782268 | — | — | 1 | 6.12 |
| CHEMBL4764020 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792783 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4761715 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4747679 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4752426 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4762956 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL4069428 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL4750965 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4798521 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL4797455 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL4800631 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL4799327 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL4741738 | — | IC50 | = | 373.0 | nM | 6.43 |
| CHEMBL4744165 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL4794767 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL4783240 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4754067 | — | IC50 | = | 608.0 | nM | 6.22 |
| CHEMBL4782268 | — | IC50 | = | 763.0 | nM | 6.12 |
| CHEMBL4764020 | — | IC50 | = | 4410.0 | nM | 5.36 |