Assay Detail
Binding
CHEMBL4713557
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ABCC1 (unknown origin) expressed in human NCI-H69AR cells assessed as reduction in calcein AM efflux preincubated for 30 mins followed by calcein AM addition and measured at 60 secs interval for 1 hr by fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H69AR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rational drug design of 6-substituted 4-anilino-2-phenylpyrimidines for exploration of novel ABCG2 binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.18 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.53 |
| CHEMBL4744165 | — | — | 1 | 5.39 |
| CHEMBL4754067 | — | — | 1 | 5.39 |
| CHEMBL4782268 | — | — | 1 | 5.04 |
| CHEMBL4799327 | — | — | 1 | 5.02 |
| CHEMBL4741738 | — | — | 1 | 4.68 |
| CHEMBL4747679 | — | — | 1 | - |
| CHEMBL4761715 | — | — | 1 | - |
| CHEMBL4783240 | — | — | 1 | - |
| CHEMBL4798521 | — | — | 1 | - |
| CHEMBL4794767 | — | — | 1 | - |
| CHEMBL4750965 | — | — | 1 | - |
| CHEMBL4752426 | — | — | 1 | - |
| CHEMBL4792783 | — | — | 1 | - |
| CHEMBL4800631 | — | — | 1 | - |
| CHEMBL4762956 | — | — | 1 | - |
| CHEMBL4764020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4744165 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL4754067 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL4782268 | — | IC50 | = | 9050.0 | nM | 5.04 |
| CHEMBL4799327 | — | IC50 | = | 9580.0 | nM | 5.02 |
| CHEMBL4741738 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL4747679 | — | IC50 | - | — | - | |
| CHEMBL4761715 | — | IC50 | - | — | - | |
| CHEMBL4783240 | — | IC50 | - | — | - | |
| CHEMBL4798521 | — | IC50 | - | — | - | |
| CHEMBL4794767 | — | IC50 | - | — | - | |
| CHEMBL4750965 | — | IC50 | - | — | - | |
| CHEMBL4752426 | — | IC50 | - | — | - | |
| CHEMBL4792783 | — | IC50 | - | — | - | |
| CHEMBL4800631 | — | IC50 | - | — | - | |
| CHEMBL4762956 | — | IC50 | - | — | - | |
| CHEMBL4764020 | — | IC50 | - | — | - |