Assay Detail
Functional
CHEMBL4713812
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Antiviral activity against wild type HIV-1 NL4-3 infected in MT-2 cells assessed as inhibition of viral replication in presence of 10% of fetal bovine serum by luciferase reporter gene based multicycle replication assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 8.21 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788357 | — | — | 1 | 9.22 |
| CHEMBL4792897 | — | — | 1 | 9.05 |
| CHEMBL4741251 | — | — | 1 | 8.89 |
| CHEMBL4756268 | — | — | 1 | 8.89 |
| CHEMBL4793139 | — | — | 1 | 8.85 |
| CHEMBL4758648 | — | — | 1 | 8.82 |
| CHEMBL3827379 | BMS-955176 | 2.0 | 1 | 8.74 |
| CHEMBL4171754 | — | — | 1 | 8.72 |
| CHEMBL4752384 | — | — | 1 | 8.64 |
| CHEMBL4789757 | — | — | 1 | 8.57 |
| CHEMBL4781292 | — | — | 1 | 8.52 |
| CHEMBL4757409 | — | — | 1 | 8.28 |
| CHEMBL404519 | BEVIRIMAT | 2.0 | 1 | 8.00 |
| CHEMBL4746346 | — | — | 1 | 7.89 |
| CHEMBL3775172 | — | — | 1 | 7.80 |
| CHEMBL4783794 | — | — | 1 | 7.57 |
| CHEMBL4764544 | — | — | 1 | 7.55 |
| CHEMBL4793327 | — | — | 1 | 7.00 |
| CHEMBL4743626 | — | — | 1 | 6.60 |
| CHEMBL4749786 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788357 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4792897 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4741251 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4756268 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4793139 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4758648 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3827379 | BMS-955176 | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4171754 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4752384 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4789757 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4781292 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4757409 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL404519 | BEVIRIMAT | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4746346 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3775172 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4783794 | — | EC50 | = | 26.7 | nM | 7.57 |
| CHEMBL4764544 | — | EC50 | = | 28.3 | nM | 7.55 |
| CHEMBL4793327 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4743626 | — | EC50 | = | 252.0 | nM | 6.60 |
| CHEMBL4749786 | — | EC50 | = | 306.0 | nM | 6.51 |