Assay Detail
Functional
CHEMBL4713818
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Antiviral activity against wild type HIV-1 NL4-3 infected in MT-2 cells assessed as inhibition of viral replication in presence of 40% human serum and 27 mg/ml human serum albumin by luciferase reporter gene based multicycle replication assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.00 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741251 | — | — | 1 | 8.30 |
| CHEMBL4789757 | — | — | 1 | 8.30 |
| CHEMBL4792897 | — | — | 1 | 8.24 |
| CHEMBL4171754 | — | — | 1 | 8.21 |
| CHEMBL4793139 | — | — | 1 | 8.18 |
| CHEMBL4756268 | — | — | 1 | 8.17 |
| CHEMBL4758648 | — | — | 1 | 8.15 |
| CHEMBL4788357 | — | — | 1 | 8.05 |
| CHEMBL3827379 | BMS-955176 | 2.0 | 1 | 7.94 |
| CHEMBL3775172 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741251 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4789757 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4792897 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4171754 | — | EC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4793139 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4756268 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4758648 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4788357 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL3827379 | BMS-955176 | EC50 | = | 11.5 | nM | 7.94 |
| CHEMBL3775172 | — | EC50 | = | 316.0 | nM | 6.50 |