Assay Detail
Functional
CHEMBL4713864
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Antiproliferative activity against human T98G cells overexpressing AR assessed as reduction in cell viability incubated for 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T98G |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small-Molecule HSP27 Inhibitor Abolishes Androgen Receptors in Glioblastoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.50 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2398330 | — | — | 1 | 8.73 |
| CHEMBL2398336 | — | — | 1 | 8.70 |
| CHEMBL4754687 | — | — | 1 | 8.31 |
| CHEMBL4788798 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2398330 | — | IC50 | = | 1.85 | nM | 8.73 |
| CHEMBL2398336 | — | IC50 | = | 2.01 | nM | 8.70 |
| CHEMBL4754687 | — | IC50 | = | 4.87 | nM | 8.31 |
| CHEMBL4788798 | — | IC50 | = | 5.71 | nM | 8.24 |