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Assay Detail

CHEMBL4714064

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity in human CNE-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type CNE-2
Confidence 1 — Organism
Curated By Autocuration

Target

CNE-2 (CHEMBL4296409)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovering High Potent Hsp90 Inhibitors as Antinasopharyngeal Carcinoma Agents through Fragment Assembling Approach.
Xu M,Zhao C,Zhu B,Wang L,Zhou H,Yan D,Gu Q,Xu J
J Med Chem (2021) 64 : 2010 -2023
PubMed 33543615 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.73 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4741221 1 7.40
CHEMBL4748845 1 5.80
CHEMBL4745924 1 5.80
CHEMBL4777925 1 5.80
CHEMBL4759116 1 5.75
CHEMBL109480 TANESPIMYCIN 3.0 1 5.52
CHEMBL4777557 1 5.40
CHEMBL4777111 1 5.25
CHEMBL4778213 1 4.85
CHEMBL4746322 1 -
CHEMBL4760861 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4741221 IC50 = 40.0 nM 7.40
CHEMBL4748845 IC50 = 1600.0 nM 5.80
CHEMBL4745924 IC50 = 1600.0 nM 5.80
CHEMBL4777925 IC50 = 1600.0 nM 5.80
CHEMBL4759116 IC50 = 1800.0 nM 5.75
CHEMBL109480 TANESPIMYCIN IC50 = 3030.0 nM 5.52
CHEMBL4777557 IC50 = 4000.0 nM 5.40
CHEMBL4777111 IC50 = 5600.0 nM 5.25
CHEMBL4778213 IC50 = 14100.0 nM 4.85
CHEMBL4746322 IC50 > 20000.0 nM -
CHEMBL4760861 IC50 > 20000.0 nM -