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Target Snapshot

CHEMBL4296409 Target Snapshot

CNE-2 · CELL-LINE · Homo sapiens

289Compounds
150Assays
2Approved Drugs
245.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CNE-2 as ChEMBL target CHEMBL4296409. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CNE-2
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296409
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CNE-2 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCNE-2
UniProt AccessionN/A

CNE-2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as CNE-2.

Review nameCNE-2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
4
Phase III
2
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50245.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4545915 8.28 IC50 5.2 Preclinical
CHEMBL4741221 7.4 IC50 40.0 Preclinical
CHEMBL5071942 7.16 IC50 70.0 Preclinical
CHEMBL3545097 7.0 IC50 101.0 Clinical
CHEMBL65 7.0 IC50 100.0 Preclinical
CHEMBL428690 6.92 IC50 120.0 Clinical
CHEMBL5091789 6.75 IC50 180.0 Preclinical
CHEMBL592445 6.7 IC50 200.0 Clinical
CHEMBL5568986 6.64 IC50 230.0 Preclinical
CHEMBL5079397 6.54 IC50 290.0 Preclinical
Distribution

pChEMBL Value Distribution

66
5.0
34
5.5
9
6.0
5
6.5
4
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

150
Total Assays
178
Tested Compounds
2
Assay Types
Functional — 121 assays, 178 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 117 178 5.3
organism-based format 4 0
ADME — 29 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 29 9 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine