Assay Detail
ADMET
CHEMBL4714284
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Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.65 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4778104 | — | — | 1 | 7.80 |
| CHEMBL4747291 | — | — | 1 | 7.40 |
| CHEMBL4750216 | — | — | 1 | 7.30 |
| CHEMBL4209572 | — | — | 1 | 7.20 |
| CHEMBL4776557 | — | — | 1 | 7.00 |
| CHEMBL4213447 | — | — | 1 | 6.80 |
| CHEMBL4765074 | — | — | 1 | 6.70 |
| CHEMBL4777852 | — | — | 1 | 6.50 |
| CHEMBL4213379 | — | — | 1 | 6.10 |
| CHEMBL4217846 | — | — | 1 | 6.10 |
| CHEMBL4785566 | — | — | 1 | 6.10 |
| CHEMBL4206126 | — | — | 1 | 5.90 |
| CHEMBL4757718 | — | — | 1 | 5.50 |
| CHEMBL4218374 | — | — | 1 | - |
| CHEMBL4778570 | — | — | 1 | - |
| CHEMBL4791279 | — | — | 1 | - |
| CHEMBL4750329 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4778104 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL4747291 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4750216 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL4209572 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4776557 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4213447 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4765074 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4777852 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4213379 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4217846 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4785566 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4206126 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4757718 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4218374 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4778570 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4791279 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4750329 | — | EC50 | > | 10000.0 | nM | - |