Assay Detail
Binding
CHEMBL4714415
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFRbeta in human SH-SY5Y cells preincubated for 60 mins followed by PDGF stimulation and measured after 10 mins by ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.43 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 8.25 |
| CHEMBL2420866 | — | — | 1 | 8.11 |
| CHEMBL4746488 | — | — | 1 | 7.53 |
| CHEMBL3604205 | — | — | 1 | 7.27 |
| CHEMBL444724 | — | — | 1 | 7.12 |
| CHEMBL2420867 | — | — | 1 | 7.09 |
| CHEMBL516047 | — | — | 1 | 6.63 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | - |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492399 | VERUBULIN | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL2420866 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4746488 | — | IC50 | = | 29.4 | nM | 7.53 |
| CHEMBL3604205 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL444724 | — | IC50 | = | 76.6 | nM | 7.12 |
| CHEMBL2420867 | — | IC50 | = | 80.6 | nM | 7.09 |
| CHEMBL516047 | — | IC50 | = | 231.5 | nM | 6.63 |
| CHEMBL535 | SUNITINIB | IC50 | = | 83.1 | nM | - |
| CHEMBL553 | ERLOTINIB | IC50 | = | 12.2 | nM | - |