Assay Detail
Functional
CHEMBL4714433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A-431 cells assessed as reduction in cell viability by Sulforhodamine B assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.56 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 9.05 |
| CHEMBL444724 | — | — | 1 | 8.92 |
| CHEMBL2420867 | — | — | 1 | 8.74 |
| CHEMBL2420866 | — | — | 1 | 8.60 |
| CHEMBL516047 | — | — | 1 | 8.54 |
| CHEMBL4746488 | — | — | 1 | 8.28 |
| CHEMBL3604205 | — | — | 1 | 7.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492399 | VERUBULIN | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL444724 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2420867 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2420866 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL516047 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4746488 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3604205 | — | IC50 | = | 16.3 | nM | 7.79 |