Assay Detail
Functional
CHEMBL4714435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiangiogenic activity in Leghorn chicken fertilized egg chorioallantoic membrane assessed as reduction in VEGF/bFGF stimulated neovascularization after 40 hrs by microscopic based CAM assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Gallus gallus |
| Tissue | Chorioallantoic membrane |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.00 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 5.55 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.51 |
| CHEMBL2420866 | — | — | 1 | 5.01 |
| CHEMBL2420867 | — | — | 1 | 4.54 |
| CHEMBL444724 | — | — | 1 | 4.38 |
| CHEMBL516047 | — | — | 1 | - |
| CHEMBL4746488 | — | — | 1 | - |
| CHEMBL3604205 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492399 | VERUBULIN | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2420866 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL2420867 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL444724 | — | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL516047 | — | IC50 | - | — | - | |
| CHEMBL4746488 | — | IC50 | - | — | - | |
| CHEMBL3604205 | — | IC50 | = | 130000.0 | nM | - |