Assay Detail
Binding
CHEMBL4714710
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human C-terminal His6-tagged ATX expressed in baculovirus infected Sf21 insect cells using LPC as substrate incubated for 2 hrs by rapidFire based MS/MS analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Pyridazines as Autotaxin Inhibitors for Treating Inflammatory Airway or Fibrotic Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.76 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788435 | — | — | 1 | 8.82 |
| CHEMBL4745566 | — | — | 1 | 8.80 |
| CHEMBL4758133 | — | — | 1 | 8.74 |
| CHEMBL4751395 | — | — | 1 | 8.74 |
| CHEMBL4743845 | — | — | 1 | 8.72 |
| CHEMBL4784419 | — | — | 1 | 8.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788435 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4745566 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4758133 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4751395 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4743845 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4784419 | — | IC50 | = | 1.9 | nM | 8.72 |