Assay Detail
Binding
CHEMBL4714713
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Inhibition of full length N-terminal His-tagged human NNMT using nicotinamide as substrate incubated for 2 hrs in presence of S-5'adenosyl-L-methionine by RapidFire Mass spectroscopy
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Pyrimidine-5-carboxamide Compounds as NNMT Inhibitors for Treating Diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.93 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788121 | — | — | 1 | 7.24 |
| CHEMBL4791213 | — | — | 1 | 7.13 |
| CHEMBL4760694 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788121 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4791213 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4760694 | — | IC50 | = | 385.0 | nM | 6.42 |