Assay Detail
Functional
CHEMBL4714839
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Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 5 days by SRB assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.57 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068896 | — | — | 1 | 7.24 |
| CHEMBL4757810 | — | — | 1 | 6.59 |
| CHEMBL4740775 | — | — | 1 | 4.23 |
| CHEMBL4785949 | — | — | 1 | 4.22 |
| CHEMBL4742889 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068896 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4757810 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL4740775 | — | IC50 | = | 59300.0 | nM | 4.23 |
| CHEMBL4785949 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL4742889 | — | IC50 | > | 100000.0 | nM | - |