Assay Detail
Binding
CHEMBL4714848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 15 mins followed by ATP addition and further incubated for 15 mins and measured after 80 mins by ADP-Glo reagent based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Amide Compounds as KIF18A Inhibitors for Treating Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.62 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776977 | — | — | 1 | 7.92 |
| CHEMBL4757053 | — | — | 1 | 7.58 |
| CHEMBL4759372 | — | — | 1 | 7.58 |
| CHEMBL4743666 | — | — | 1 | 7.57 |
| CHEMBL4765048 | — | — | 1 | 7.54 |
| CHEMBL4786845 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776977 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4757053 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4759372 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4743666 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4765048 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4786845 | — | IC50 | = | 29.0 | nM | 7.54 |