Assay Detail
Binding
CHEMBL4714985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ACVR2A (unknown origin) using biotin- labelled KTLQDLVYDLSTSGSGSGLPLFVQRTVART substrate in presence of [gamma33P] ATP measured after 20 min
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Selective Transforming Growth Factor β Type II Receptor Inhibitors as Antifibrosis Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.82 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792978 | — | — | 1 | 6.75 |
| CHEMBL4741913 | — | — | 1 | 6.72 |
| CHEMBL4752199 | — | — | 1 | 6.51 |
| CHEMBL4749011 | — | — | 1 | 6.28 |
| CHEMBL4744988 | — | — | 1 | 6.20 |
| CHEMBL4741185 | — | — | 1 | 6.16 |
| CHEMBL4747422 | — | — | 1 | 6.10 |
| CHEMBL4744618 | — | — | 1 | 6.07 |
| CHEMBL4763122 | — | — | 1 | 6.02 |
| CHEMBL4795223 | — | — | 1 | 5.96 |
| CHEMBL4798505 | — | — | 1 | 5.92 |
| CHEMBL4750258 | — | — | 1 | 5.92 |
| CHEMBL4779579 | — | — | 1 | 5.89 |
| CHEMBL4783244 | — | — | 1 | 5.89 |
| CHEMBL4779273 | — | — | 1 | 5.72 |
| CHEMBL4791414 | — | — | 1 | 5.64 |
| CHEMBL4758580 | — | — | 1 | 5.64 |
| CHEMBL4787891 | — | — | 1 | 5.62 |
| CHEMBL4764416 | — | — | 1 | 5.57 |
| CHEMBL4782729 | — | — | 1 | 5.54 |
| CHEMBL4764221 | — | — | 1 | 5.54 |
| CHEMBL4777071 | — | — | 1 | 5.52 |
| CHEMBL4763627 | — | — | 1 | 5.52 |
| CHEMBL4751832 | — | — | 1 | 5.52 |
| CHEMBL4748097 | — | — | 1 | 5.42 |
| CHEMBL4792464 | — | — | 1 | 5.39 |
| CHEMBL4749061 | — | — | 1 | 5.28 |
| CHEMBL4747912 | — | — | 1 | 4.70 |
| CHEMBL4745367 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792978 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4741913 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4752199 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4749011 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4744988 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4741185 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4747422 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4744618 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4763122 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4795223 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4798505 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4750258 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4779579 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4783244 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4779273 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4791414 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4758580 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4787891 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4764416 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4782729 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4764221 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4777071 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4763627 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4751832 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4748097 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4792464 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4749061 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4747912 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4745367 | — | IC50 | > | 20000.0 | nM | - |