Compound Detail
CHEMBL4749011
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Basic Information
| ChEMBL ID | CHEMBL4749011 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IMYRHBGHTRQBCA-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
336.4
MW (Da)
2.21
ALogP
8
HBA
0
HBD
79.4
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.27 | 7.27 | 54.0 | 1 |
| Activin receptor type-2A CHEMBL5616 | IC50 | 6.28 | 6.28 | 530.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 54.0 | nM | 7.27 | Inhibition of TGFbeta-1-induced Smad3 phosphorylation in human Epi293F cells pre... | 34055221 |
| Activin receptor type-2A | IC50 | = | 530.0 | nM | 6.28 | Inhibition of ACVR2A (unknown origin) using biotin- labelled KTLQDLVYDLSTSGSGSGL... | 34055221 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34055221 | 10.1021/acsmedchemlett.0c00679 | Unchecked | 2 |
| 34055221 | 10.1021/acsmedchemlett.0c00679 | ADMET | 2 |
| 34055221 | 10.1021/acsmedchemlett.0c00679 | TGF-beta receptor type-2 | 1 |
| 34055221 | 10.1021/acsmedchemlett.0c00679 | Activin receptor type-2A | 1 |
Data from ChEMBL 36 via Core Engine